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Panther + Expel: Bringing AI-Powered SIEM and MDR Together

Katie

Campisi

Dec 16, 2025

Panther and Expel are announcing a new native integration that brings modern, AI-powered SIEM and MDR into a unified workflow.

Security teams need high-quality detections, fast response, and flexibility to use best-in-class tools without architectural trade-offs. This new Panther & Expel integration is designed to support that model: Panther serves as the system of record for detections and alert quality, while Expel provides 24×7 monitoring, triage, and investigation to fortify security operations.

At the integration level, Panther now delivers alerts directly to Expel in real time using a native, webhook-based alert destination. When a detection fires, Panther sends an authenticated, enriched alert to Expel’s platform, including sampled events for immediate context. This removes the need for scheduled polling and allows alerts to flow immediately from detection to response.

This approach reflects Panther's broader approach to extensibility. Security teams don’t operate within a single platform, and Panther is built to integrate seamlessly with the entire security stack, including MDR providers, ticketing systems, and custom logs and workflows.

For teams operating in high-scale environments, this shifts alert delivery from inefficient polling to an event-driven architecture, improving response times and optimizing costs. From an architectural standpoint, the separation of responsibilities enables Panther to serve as the source of truth for detection logic, enrichment, and alert quality, while Expel consumes those alerts as a downstream responder, providing 24×7 monitoring, triage, and investigation. 

The operational impact shows up in measurable KPIs:

  • Improved MTTD and MTTR 

  • More predictable costs

  • Faster audits for demonstrating compliance 

Setup is intentionally simple. Enable the Expel alert destination in Panther, provide Basic Auth credentials, and alerts begin flowing immediately. There’s no secondary pipeline to maintain and no duplicate alerting logic to reconcile. Follow the docs to set up the Panther and Expel integration. 

For teams running lean security programs, this integration removes a typical trade-off. You can run a modern security operations program, integrate with best-in-class MDR, and still preserve detection speed, data control, and cost efficiency.

Learn how Panther and Expel work together in practice. Request a Panther demo here. 

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